
關于使用rs3057來判定東亞人絕對音準的疑惑
因為我本身是非常確定自己有絕對音準的,但是看到顯示的是可能性較小的基因型TT,感到很奇怪于是去查了一下你們這里列出來的參考文獻,下面quote:
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"Examining data for the Eu families alone, we detected one region, with a maximum LOD score at rs3057 on chromosome 8q24.21 (Figure?1B), that showed strong evidence for linkage, having a nonparametric multipoint exponential LOD score of 3.464 (empirical genome-wide p = .0300)."
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"Using the E Asian families, we observed that no linkage peak exceeded the empirical threshold for suggestive linkage (LOD = 1.822), but regions on chromosomes 1, 3, 7, 13, 18 and 19 had linkage peaks with LOD scores greater than 1.0 (Figure?1C and?Table 3). Notably, there was no evidence in the E Asian population for linkage in the region of significant linkage (8q24.21) from the Eu sample set. In fact, the chromosome 7 region was the only E Asian region with a LOD score over 1.0 that showed overlap with linkage peaks observed in the Eu data set ."
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文里面已經說了8號染色體上的rs3057是對于那些歐洲血統的人有重要關聯的,而且還強調說東亞人的linkage根本沒證據顯示是跟chr. 8q24.21有關,反而是和chr.?1,3,7,13,18,19有關。
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WEGENE這里用chr.8上面的rs3057來判定歐洲血統的人可信度是高,但是用來判定我們這些東亞人具有絕對音準的可能性的話....我也只能表示一臉黑人問號...所以說我個人認為這個結果是比較有誤導性的。
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"Examining data for the Eu families alone, we detected one region, with a maximum LOD score at rs3057 on chromosome 8q24.21 (Figure?1B), that showed strong evidence for linkage, having a nonparametric multipoint exponential LOD score of 3.464 (empirical genome-wide p = .0300)."
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"Using the E Asian families, we observed that no linkage peak exceeded the empirical threshold for suggestive linkage (LOD = 1.822), but regions on chromosomes 1, 3, 7, 13, 18 and 19 had linkage peaks with LOD scores greater than 1.0 (Figure?1C and?Table 3). Notably, there was no evidence in the E Asian population for linkage in the region of significant linkage (8q24.21) from the Eu sample set. In fact, the chromosome 7 region was the only E Asian region with a LOD score over 1.0 that showed overlap with linkage peaks observed in the Eu data set ."
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文里面已經說了8號染色體上的rs3057是對于那些歐洲血統的人有重要關聯的,而且還強調說東亞人的linkage根本沒證據顯示是跟chr. 8q24.21有關,反而是和chr.?1,3,7,13,18,19有關。
?
WEGENE這里用chr.8上面的rs3057來判定歐洲血統的人可信度是高,但是用來判定我們這些東亞人具有絕對音準的可能性的話....我也只能表示一臉黑人問號...所以說我個人認為這個結果是比較有誤導性的。
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